The Reds have lost to Premier League title rivals Manchester City and then Wolves in the FA Cup third round in their last two games but they remain four points clear at the top ahead of Saturday's clash with Brighton.
Firmino wants Jurgen Klopp's men to bounce back but knows they will be tested on the south coast.
He told the club's website: "It’ll be a difficult game. Losing is obviously always bad; nobody likes to lose, and certainly not me. But now we’ve got to bounce back.
"We’ve worked hard every day so we’re prepared for the weekend. It’ll be a big game, a difficult game and we’ll do our best to get the three points."
Firmino is well aware City are waiting to pounce should Liverpool slip up again and he's called for the squad to refocus for the second half of the campaign.
He added: "That’s what the Premier League is all about - it’s intensely competitive. If the team at the top stutters, the second place will overtake them. We know we can’t go to sleep and lose silly points. We must maintain our focus until the end of the season."
Firmino has rediscovered his goal touch in recent weeks and has four in his last two league games so he's aiming for more at the Amex Stadium.
He said: "I’ve always loved scoring; I love to help my team with assists and goals. It’s what I always go out there with the aim of going to do. I love football and will do my best on the pitch. I’m really happy with everything at the moment."