The Shakers appeared to come through the 1-0 win over Stevenage last weekend without sustaining any fresh injuries.
Stephen Dawson (foot) and Jermaine Beckford (knee) are long-term absentees.
Lowe's second-placed side are unbeaten in their last 13 Sky Bet League Two matches.
Cambridge, 19th in the table, are set to once again be without Brad Halliday.
Boss Colin Calderwood has revealed the defender, who sat out Tuesday's 0-0 draw with Crewe, has picked up an illness and looks likely to miss this contest as well.
Midfielder George Maris is expected to be available after taking a bang to the shoulder.
Liam O'Neil continues to be sidelined with his hip issue.
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